EBV LMP1, a viral mimic of CD40, activates dendritic cells and functions as a molecular adjuvant when incorporated into an HIV vaccine

HIV-1 does not significantly activate cellular immunity, which has made it difficult to use attenuated forms of HIV-1 as a vaccine. In contrast, EBV induces robust T cell responses in most infected individuals, perhaps as this virus contains LMP1, a viral mimic of CD40, which is a key activating mol...

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Bibliographic Details
Main Authors: Gupta, Sachin, Termini, James M., Niu, Liguo, Kanagavelu, Saravana K., Schmidtmayerova, Helena, Snarsky, Victoria, Kornbluth, Richard S., Stone, Geoffrey W.
Format: Artigo
Language:Inglês
Published: Society for Leukocyte Biology 2011
Subjects:
Translational & Clinical Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133438/
https://ncbi.nlm.nih.gov/pubmed/21586676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0211068
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