Calcium/calmodulin-dependent protein kinase (CaMK) Iα mediates the macrophage inflammatory response to sepsis

Dysregulated Ca(2+) handling is prevalent during sepsis and postulated to perpetuate the aberrant inflammation underlying subsequent organ dysfunction and death. The signal transduction cascades mediating these processes are unknown. Here, we identify that CaMKIα mediates the Mφ response to LPS in v...

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Bibliographic Details
Main Authors: Zhang, Xianghong, Guo, Lanping, Collage, Richard D., Stripay, Jennifer L., Tsung, Allan, Lee, Janet S., Rosengart, Matthew R.
Format: Artigo
Language:Inglês
Published: Society for Leukocyte Biology 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133437/
https://ncbi.nlm.nih.gov/pubmed/21372190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0510286
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