Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during LPS stimulation of macrophages

The chromatin-binding factor HMGB1 functions as a proinflammatory cytokine and late mediator of mortality in murine endotoxemia. Although serine phosphorylation of HMGB1 is necessary for nucleocytoplasmic shuttling prior to its cellular release, the protein kinases involved have not been identified....

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Main Authors: Zhang, Xianghong, Wheeler, David, Tang, Ying, Guo, Lanping, Shapiro, Richard A., Ribar, Thomas J., Means, Anthony R., Billiar, Timothy R., Angus, Derek C., Rosengart, Matthew R.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587501/
https://ncbi.nlm.nih.gov/pubmed/18802105
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