Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during LPS stimulation of macrophages

The chromatin-binding factor HMGB1 functions as a proinflammatory cytokine and late mediator of mortality in murine endotoxemia. Although serine phosphorylation of HMGB1 is necessary for nucleocytoplasmic shuttling prior to its cellular release, the protein kinases involved have not been identified....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Xianghong, Wheeler, David, Tang, Ying, Guo, Lanping, Shapiro, Richard A., Ribar, Thomas J., Means, Anthony R., Billiar, Timothy R., Angus, Derek C., Rosengart, Matthew R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587501/
https://ncbi.nlm.nih.gov/pubmed/18802105
Tagiau: Ychwanegu Tag
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