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mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

Mutational inactivation of the tumor suppressor tuberous sclerosis complex 2 (TSC2) constitutively activates mTORC1, increases cell proliferation, and induces the pathological manifestations observed in tuberous sclerosis (TS) and in pulmonary lymphangioleiomyomatosis (LAM). While the role of mTORC1...

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書誌詳細
主要な著者: Goncharova, Elena A., Goncharov, Dmitry A., Li, Hua, Pimtong, Wittaya, Lu, Stephen, Khavin, Irene, Krymskaya, Vera P.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133430/
https://ncbi.nlm.nih.gov/pubmed/21482669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01061-10
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