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mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells
Mutational inactivation of the tumor suppressor tuberous sclerosis complex 2 (TSC2) constitutively activates mTORC1, increases cell proliferation, and induces the pathological manifestations observed in tuberous sclerosis (TS) and in pulmonary lymphangioleiomyomatosis (LAM). While the role of mTORC1...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133430/ https://ncbi.nlm.nih.gov/pubmed/21482669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01061-10 |
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