Phenotypes in mTERT(+/−) and mTERT(−/−) Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase

Telomerase is essential for telomere length maintenance. Mutations in either of the two core components of telomerase, telomerase RNA (TR) or the catalytic protein component telomerase reverse transcriptase (TERT), cause the genetic disorders dyskeratosis congenita, pulmonary fibrosis, and other deg...

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Autores principales: Strong, Margaret A., Vidal-Cardenas, Sofia L., Karim, Baktiar, Yu, Huimin, Guo, Nini, Greider, Carol W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133422/
https://ncbi.nlm.nih.gov/pubmed/21464209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05312-11
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