Human Epidermal Growth Factor Receptor (EGFR) Aligned on the Plasma Membrane Adopts Key Features of Drosophila EGFR Asymmetry

The ability of epidermal growth factor receptor (EGFR) to control cell fate is defined by its affinity for ligand. Current models suggest that ligand-binding heterogeneity arises from negative cooperativity in signaling receptor dimers, for which the asymmetry of the extracellular region of the Dros...

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Detalhes bibliográficos
Main Authors: Tynan, Christopher J., Roberts, Selene K., Rolfe, Daniel J., Clarke, David T., Loeffler, Hannes H., Kästner, Johannes, Winn, Martyn D., Parker, Peter J., Martin-Fernandez, Marisa L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133235/
https://ncbi.nlm.nih.gov/pubmed/21444717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01431-10
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