Single-Molecule Imaging and Fluorescence Lifetime Imaging Microscopy Show Different Structures for High- and Low-Affinity Epidermal Growth Factor Receptors in A431 Cells()

Epidermal growth factor (EGF) receptor (EGFR) modulates mitosis and apoptosis through signaling by its high-affinity (HA) and low-affinity (LA) EGF-binding states. The prevailing model of EGFR activation—derived from x-ray crystallography—involves the transition from tethered ectodomain monomers to...

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Detalhes bibliográficos
Main Authors: Webb, Stephen E.D., Roberts, Selene K., Needham, Sarah R., Tynan, Christopher J., Rolfe, Daniel J., Winn, Martyn D., Clarke, David T., Barraclough, Roger, Martin-Fernandez, Marisa L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Channels, Receptors, and Electrical Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2186246/
https://ncbi.nlm.nih.gov/pubmed/17890389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.112623
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