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Efficient Extension of Slipped DNA Intermediates by DinB Is Required To Escape Primer Template Realignment by DnaQ

We show that Escherichia coli DinB polymerase, which creates single-base deletions, prefers to extend slipped DNA substrates with the skipped base at the −4 position. A DinB(Y79L) variant, which extends these substrates less efficiently in vitro, allows the proofreading function of polymerase III to...

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Detalhes bibliográficos
Main Authors: Foti, James J., Walker, Graham C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133156/
https://ncbi.nlm.nih.gov/pubmed/21421753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00005-11
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