Pigment Epithelium-Derived Factor Blocks Tumor Extravasation by Suppressing Amoeboid Morphology and Mesenchymal Proteolysis

Metastatic melanoma cells are highly adaptable to their in vivo microenvironment and can switch between protease-dependent mesenchymal and protease-independent amoeboid invasion to facilitate metastasis. Such adaptability can be visualized in vitro, when cells are cultured in conditions that recapit...

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Autors principals: Ladhani, Omar, Sánchez-Martinez, Cristina, Orgaz, Jose L, Jimenez, Benilde, Volpert, Olga V
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132849/
https://ncbi.nlm.nih.gov/pubmed/21750657
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