Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma

Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that displays broad anti-tumor activity based on dual targeting of the tumor microenvironment (anti-angiogenic action) and the tumor cells (direct anti-tumor action). Here we show that PEDF expression is high in mela...

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Main Authors: Orgaz, JL, Ladhani, O, Hoek, KS, Fernández-Barral, A, Mihic, D, Aguilera, O, Seftor, EA, Bernad, A, Rodríguez-Peralto, JL, Hendrix, MJC, Volpert, OV, Jiménez, B
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873770/
https://ncbi.nlm.nih.gov/pubmed/19767774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.284
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