Compensation mechanism in tumor cell migration: mesenchymal–amoeboid transition after blocking of pericellular proteolysis

Invasive tumor dissemination in vitro and in vivo involves the proteolytic degradation of ECM barriers. This process, however, is only incompletely attenuated by protease inhibitor–based treatment, suggesting the existence of migratory compensation strategies. In three-dimensional collagen matrices,...

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Autores principales: Wolf, Katarina, Mazo, Irina, Leung, Harry, Engelke, Katharina, von Andrian, Ulrich H., Deryugina, Elena I., Strongin, Alex Y., Bröcker, Eva-B., Friedl, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2003
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172637/
https://ncbi.nlm.nih.gov/pubmed/12527751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200209006
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