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Compensation mechanism in tumor cell migration: mesenchymal–amoeboid transition after blocking of pericellular proteolysis

Invasive tumor dissemination in vitro and in vivo involves the proteolytic degradation of ECM barriers. This process, however, is only incompletely attenuated by protease inhibitor–based treatment, suggesting the existence of migratory compensation strategies. In three-dimensional collagen matrices,...

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Hlavní autoři: Wolf, Katarina, Mazo, Irina, Leung, Harry, Engelke, Katharina, von Andrian, Ulrich H., Deryugina, Elena I., Strongin, Alex Y., Bröcker, Eva-B., Friedl, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172637/
https://ncbi.nlm.nih.gov/pubmed/12527751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200209006
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