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Single-point mutations of a lysine residue change function of Bax and Bcl-x(L) expressed in Bax- and Bak-less mouse embryonic fibroblasts: novel insights into the molecular mechanisms of Bax-induced apoptosis

Members of the Bcl-2 family play key roles as proapoptotic (e.g., Bax) and antiapoptotic (e.g., Bcl-x(L)) regulators of programmed cell death. We previously identified the mitochondrial potassium channel Kv1.3 as a novel target of Bax. Incubating Kv1.3-positive isolated mitochondria with Bax trigger...

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Detalhes bibliográficos
Main Authors: Szabò, I, Soddemann, M, Leanza, L, Zoratti, M, Gulbins, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132001/
https://ncbi.nlm.nih.gov/pubmed/20885444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.112
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