Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

The potassium channel Kv1.3 has recently been located to the inner mitochondrial membrane of lymphocytes. Here, we show that mouse and human cells that are genetically deficient in either Kv1.3 or transfected with siRNA to suppress Kv1.3-expression resisted apoptosis induced by several stimuli, incl...

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Bibliografiske detaljer
Main Authors: Szabó, Ildikò, Bock, Jürgen, Grassmé, Heike, Soddemann, Matthias, Wilker, Barbara, Lang, Florian, Zoratti, Mario, Gulbins, Erich
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567458/
https://ncbi.nlm.nih.gov/pubmed/18818304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804236105
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