Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

The n-type K(+) channel (n-K(+), K(v)1.3) in lymphocytes has been recently implicated in the regulation of Fas-induced programmed cell death. Here, we demonstrate that ceramide, a lipid metabolite synthesized upon Fas receptor ligation, inhibits n-K(+) channel activity and induces a tyrosine phospho...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Gulbins, Erich, Szabo, Ildiko, Baltzer, Katharina, Lang, Florian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207149/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.14.7661
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