Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α(5)β(1)-integrin

Anoikis resistance is a hallmark of transformed epithelial cells. Here, we show that treatment of anoikis-resistant carcinoma cell lines with the endogenous lectin galectin-1 (Gal-1) promoted apoptosis via interaction with the unligated fibronectin receptor α(5)β(1)-integrin. Gal-1 efficiency correl...

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Autores principales: Sanchez-Ruderisch, H, Detjen, K M, Welzel, M, André, S, Fischer, C, Gabius, H-J, Rosewicz, S
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
Materias:
Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131929/
https://ncbi.nlm.nih.gov/pubmed/21113146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.148
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