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Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α(5)β(1)-integrin
Anoikis resistance is a hallmark of transformed epithelial cells. Here, we show that treatment of anoikis-resistant carcinoma cell lines with the endogenous lectin galectin-1 (Gal-1) promoted apoptosis via interaction with the unligated fibronectin receptor α(5)β(1)-integrin. Gal-1 efficiency correl...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131929/ https://ncbi.nlm.nih.gov/pubmed/21113146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.148 |
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