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A Novel Function for the Tumor Suppressor p16(INK4a) : Induction of Anoikis via Upregulation of the α(5)β(1) Fibronectin Receptor
The tumor suppressor gene p16(INK4a) inhibits the kinase activity of the cyclin-dependent kinase 4–6/cyclin D complexes and subsequent phosphorylation of critical substrates necessary for transit through the G1 phase of the cell cycle. Recent studies suggested that control of the G1/S boundary might...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2150704/ https://ncbi.nlm.nih.gov/pubmed/10995450 |
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