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SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence
Oncogene-induced senescence represents a key tumor suppressive mechanism. Here, we show that Ras oncogene-induced senescence can be mediated by the recently identified haploinsufficient tumor suppressor apoptosis-stimulating protein of p53 (ASPP) 2 through a novel and p53/p19(Arf)/p21(waf1/cip1)-ind...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131893/ https://ncbi.nlm.nih.gov/pubmed/20798689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.101 |
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