SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

Oncogene-induced senescence represents a key tumor suppressive mechanism. Here, we show that Ras oncogene-induced senescence can be mediated by the recently identified haploinsufficient tumor suppressor apoptosis-stimulating protein of p53 (ASPP) 2 through a novel and p53/p19(Arf)/p21(waf1/cip1)-ind...

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Autors principals: Wang, X D, Lapi, E, Sullivan, A, Ratnayaka, I, Goldin, R, Hay, R, Lu, X
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131893/
https://ncbi.nlm.nih.gov/pubmed/20798689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.101
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