Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

The sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) have recently been implicated in autophagy. In this study, we report that depletion of sphingosine-1-phosphate phosphohydrolase-1 (SPP1), an endoplasmic reticulum (ER)-resident enzyme that specifically dephosphorylates S1P, indu...

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Bibliografiske detaljer
Main Authors: Lépine, S, Allegood, J C, Park, M, Dent, P, Milstien, S, Spiegel, S
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131882/
https://ncbi.nlm.nih.gov/pubmed/20798685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.104
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