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Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage

Sphingosine 1-phosphate (S1P) and ceramide have been implicated in both autophagy and apoptosis. However, the roles of these sphingolipid metabolites in the links between these two processes are not completely understood. Depletion of S1P phosphohydrolase-1 (SPP1), which degrades intracellular S1P,...

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Bibliografiske detaljer
Main Authors: Lépine, Sandrine, Allegood, Jeremy C., Edmonds, Yvette, Milstien, Sheldon, Spiegel, Sarah
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247960/
https://ncbi.nlm.nih.gov/pubmed/22052905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.257519
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