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Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion
The extrinsic, or death receptor, pathway integrates apoptotic signals through the protease caspase-8 (casp8). Beyond cell death regulation, non-apoptotic functions of casp8 include its essential requirement for hematopoiesis and lymphocyte clonal expansion, and tempering of autophagy in T cells. Ho...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131867/ https://ncbi.nlm.nih.gov/pubmed/20523353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.69 |
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