A positive role for c-Abl in Atm and Atr activation in DNA damage response

DNA damage triggers Atm- and/or Atr-dependent signaling pathways to control cell cycle progression, apoptosis, and DNA repair. However, how Atm and Atr are activated is not fully understood. One of the downstream targets of Atm is non-receptor tyrosine kinase c-Abl, which is phosphorylated and activ...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Wang, X, Zeng, L, Wang, J, Chau, J F L, Lai, K P, Jia, D, Poonepalli, A, Hande, M P, Liu, H, He, G, He, L, Li, B
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2011
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131864/
https://ncbi.nlm.nih.gov/pubmed/20798688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.106
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