Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)

New regulatory roles continue to emerge for both natural and engineered noncoding RNAs, many of which have specific secondary and tertiary structures essential to their function. Thus there is a growing need to develop technologies that enable rapid characterization of structural features within com...

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Hauptverfasser: Lucks, Julius B., Mortimer, Stefanie A., Trapnell, Cole, Luo, Shujun, Aviran, Sharon, Schroth, Gary P., Pachter, Lior, Doudna, Jennifer A., Arkin, Adam P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131332/
https://ncbi.nlm.nih.gov/pubmed/21642531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106501108
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