Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

Oil-in-water emulsions have been successfully used to increase the efficacy, immunogenicity, and cross-protection of human vaccines; however, their mechanism of action is still largely unknown. Nlrp3 inflammasome has been previously associated to the activity of alum, another adjuvant broadly used i...

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Bibliografiske detaljer
Main Authors: Seubert, Anja, Calabro, Samuele, Santini, Laura, Galli, Barbara, Genovese, Alessia, Valentini, Sara, Aprea, Susanna, Colaprico, Annalisa, D'Oro, Ugo, Giuliani, Marzia M., Pallaoro, Michele, Pizza, Mariagrazia, O'Hagan, Derek T., Wack, Andreas, Rappuoli, Rino, De Gregorio, Ennio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131326/
https://ncbi.nlm.nih.gov/pubmed/21690334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107941108
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