Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus

BACKGROUND AND PURPOSE: Patients with diabetes mellitus require pharmacotherapy with numerous medications. However, the effect of diabetes on drug biotransformation is not well understood. Our goal was to investigate the effect of diabetes on liver cytochrome P450 3As, the most abundant phase I drug...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dostalek, Miroslav, Court, Michael H, Yan, Bingfang, Akhlaghi, Fatemeh
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Blackwell Science Inc 2011
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130941/
https://ncbi.nlm.nih.gov/pubmed/21323901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01270.x
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