Canine cytochrome P450 (CYP) pharmacogenetics

le Court, Michael H.
Foilsithe 2013

Feline drug metabolism and disposition: pharmacokinetic evidence for species differences and molecular mechanisms

le Court, Michael H.
Foilsithe 2013

Interindividual variability in hepatic drug glucuronidation: Studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model syst...

le Court, Michael H.
Foilsithe in Drug Metab Rev (2010)

Effect of the β-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases (UGTs)

le Oleson, Lauren, Court, Michael H.
Foilsithe 2008

Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach

le Papageorgiou, Ioannis, Court, Michael H.
Foilsithe in Biochem Pharmacol (2017)

Identification and validation of the microRNA response elements in the 3’-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics a...

le Papageorgiou, Ioannis, Court, Michael H.
Foilsithe in Biochem Pharmacol (2017)

Role for Protein Kinase C Delta in the Functional Activity of Human UGT1A6: Implications for Drug-Drug Interactions between PKC Inhibitors and UGT1A6.

le Volak, Laurie P., Court, Michael H.
Foilsithe in Xenobiotica (2010)

Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver

le Papageorgiou, Ioannis, Freytsis, Marina, Court, Michael H.
Foilsithe in Biochem Pharmacol (2016)

Diabetes Mellitus Reduces Activity of Human UDP-Glucuronosyltransferase 2B7 in Liver and Kidney Leading to Decreased Formation of Mycophenolic Acid Acyl-Glucuronide Metabolite

le Dostalek, Miroslav, Court, Michael H., Hazarika, Suwagmani, Akhlaghi, Fatemeh
Foilsithe 2011

Significantly reduced cytochrome P450 3A4 expression and activity in liver from humans with diabetes mellitus

le Dostalek, Miroslav, Court, Michael H, Yan, Bingfang, Akhlaghi, Fatemeh
Foilsithe 2011

Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma

le Lyngby, Janne G., Court, Michael H., Lee, Pamela M.
Foilsithe in J Vet Cardiol (2017)

Soy isoflavone metabolism in cats compared with other species: Urinary metabolite concentrations and glucuronidation by liver microsomes

le Redmon, Joanna M., Shrestha, Binu, Cerundolo, Rosario, Court, Michael H.
Foilsithe in Xenobiotica (2015)

Bisphenol-A glucuronidation in human liver and breast: Identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms

le Street, Christina M., Zhu, Zhaohui, Finel, Moshe, Court, Michael H.
Foilsithe in Xenobiotica (2016)

Paradoxically Elevated Efavirenz Concentrations in HIV/TB Co-infected Patients with CYP2B6 516TT Genotype on Rifampin-containing Antituberculous Therapy

le Kwara, Awewura, Lartey, Margaret, Sagoe, Kwamena W., Court, Michael H.
Foilsithe in AIDS (2011)

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers

le Yasar, Umit, Greenblatt, David J, Guillemette, Chantal, Court, Michael H
Foilsithe in J Pharm Pharmacol (2013)

Grapefruit juice, lyophilized grapefruit juice, and powdered whole grapefruit inhibit cytochrome P450 mediated triazolam hydroxylation by beagle dog liver microsomes

le Hanley, Michael J., Cerundolo, Rosario, Radwanski, Noel, Court, Michael H.
Foilsithe in J Vet Pharmacol Ther (2010)

Curcuminoids inhibit multiple human cytochromes P450 (CYP), UDP-glucuronosyltransferase (UGT), and sulfotransferase (SULT) enzymes, while piperine is a relatively selective CYP3A4...

le Volak, Laurie P., Ghirmai, Senait, Cashman, John R., Court, Michael H.
Foilsithe 2008

Preliminary Pharmacokinetics and Cardiovascular Effects of Fenoldopam Continuous Rate Infusion in 6 Healthy Dogs

le Bloom, Carly Anne, Labato, Mary Anna, Hazarika, Suwagmani, Court, Michael H.
Foilsithe 2011

Novel polymorphic human UDP-glucuronosyltransferase (UGT) 2A3: Cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction

le Court, Michael H., Hazarika, Suwagmani, Krishnaswamy, Soundararajan, Finel, Moshe, Williams, J. Andrew
Foilsithe 2008

Identification of Polymorphisms in the 3′-Untranslated Region of the Human Pregnane X Receptor (PXR) Gene Associated with Variability in Cytochrome P450 3A (CYP3A) Metabolism

le Oleson, Lauren, von Moltke, Lisa L., Greenblatt, David J., Court, Michael H.
Foilsithe 2010