Angiotensin II Activation of mTOR Results in Tubulointerstitial Fibrosis through Loss of N-Cadherin

BACKGROUND/AIMS: Angiotensin (Ang) II contributes to tubulointerstitial fibrosis. Recent data highlight mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) signaling in tubulointerstitial fibrosis; however, the mechanisms remain unclear. Thereby, we investigated the role of Ang II on mTOR/S6K1-d...

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Bibliografske podrobnosti
Main Authors: Whaley-Connell, Adam, Habibi, Javad, Panfili, Zachary, Hayden, Melvin R., Bagree, Sarika, Nistala, Ravi, Hyder, Safwan, Krueger, Bennett, DeMarco, Vincent, Pulakat, Lakshmi, Ferrario, Carlos M., Parrish, Alan, Sowers, James R.
Format: Artigo
Jezik:Inglês
Izdano: S. Karger AG 2011
Teme:
Original Report: Laboratory Investigation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130895/
https://ncbi.nlm.nih.gov/pubmed/21720156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000329327
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