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siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency
Small interfering RNAs (siRNAs) are routinely used to reduce mRNA levels for a specific gene with the goal of studying its function. Several studies have demonstrated that siRNAs are not always specific and can have many off-target effects. The 3′ UTRs of off-target mRNAs are often enriched in seque...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3130022/ https://ncbi.nlm.nih.gov/pubmed/21750714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021503 |
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