siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency

Small interfering RNAs (siRNAs) are routinely used to reduce mRNA levels for a specific gene with the goal of studying its function. Several studies have demonstrated that siRNAs are not always specific and can have many off-target effects. The 3′ UTRs of off-target mRNAs are often enriched in seque...

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Detalhes bibliográficos
Main Authors: Caffrey, Daniel R., Zhao, Juan, Song, Zhili, Schaffer, Michael E., Haney, Steven A., Subramanian, Romesh R., Seymour, Albert B., Hughes, Jason D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130022/
https://ncbi.nlm.nih.gov/pubmed/21750714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021503
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