Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

MicroRNAs (miRNAs) are emerging as potential cancer therapeutics, but effective delivery mechanisms to tumor sites are a roadblock to utility. Here we show that systemically delivered, synthetic miRNA mimics in complex with a novel neutral lipid emulsion are preferentially targeted to lung tumors an...

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Bibliographic Details
Main Authors: Trang, Phong, Wiggins, Jason F, Daige, Christopher L, Cho, Chris, Omotola, Michael, Brown, David, Weidhaas, Joanne B, Bader, Andreas G, Slack, Frank J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129804/
https://ncbi.nlm.nih.gov/pubmed/21427705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.48
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