Engineering Liver-detargeted AAV9 Vectors for Cardiac and Musculoskeletal Gene Transfer

We report the generation of a new class of adeno-associated virus serotype 9 (AAV9)-derived vectors displaying selective loss of liver tropism and demonstrating potential for cardiac and musculoskeletal gene transfer applications. Random mutagenesis of residues within a surface-exposed region of the...

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Autors principals: Pulicherla, Nagesh, Shen, Shen, Yadav, Swati, Debbink, Kari, Govindasamy, Lakshmanan, Agbandje-McKenna, Mavis, Asokan, Aravind
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129791/
https://ncbi.nlm.nih.gov/pubmed/21364538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.22
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