GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells

BACKGROUND: Aromatase inhibitors (AI) that inhibit breast cancer cell growth by blocking estrogen synthesis have become the treatment of choice for post-menopausal women with estrogen receptor positive (ER(+)) breast cancer. However, some patients display de novo or acquired resistance to AI. Intera...

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Main Authors: Abrhale, Tesfom, Brodie, Angela, Sabnis, Gauri, Macedo, Luciana, Tian, Changsheng, Yue, Binbin, Serrero, Ginette
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129588/
https://ncbi.nlm.nih.gov/pubmed/21658239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-231
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