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Signaling Pathway of GP88 (Progranulin) in Breast Cancer Cells: Upregulation and Phosphorylation of c-myc by GP88/Progranulin in Her2-Overexpressing Breast Cancer Cells

Her2 is a receptor tyrosine kinase overexpressed in 25% of breast tumors. We have shown that the 88 kDa autocrine growth and survival factor GP88 (progranulin) stimulated Her2 phosphorylation and proliferation and conferred Herceptin resistance in Her2-overexpressing cells. Herein, we report that GP...

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Détails bibliographiques
Auteurs principaux: Wes E. Kim, Binbin Yue, Ginette Serrero
Format: Artigo
Langue:Inglês
Publié: SAGE Publishing 2015-01-01
Collection:Breast Cancer: Basic and Clinical Research
Accès en ligne:https://doi.org/10.4137/BCBCR.S29371
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