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Coverage tradeoffs and power estimation in the design of whole-genome sequencing experiments for detecting association
Motivation: Whole-genome sequencing (WGS) allows direct interrogation of previously undetected uncommon or rare variants, which potentially contribute to the missing heritability of human disease. However, cost of sequencing large numbers of samples limits its application in case–control association...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3129526/ https://ncbi.nlm.nih.gov/pubmed/21636589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btr305 |
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