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Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such as broccoli. The ability of SFN to inhibit histone deacetylase enzymes may be one mechanism by which it acts as a chemoprevention agent. The ability of a chemopreventive agent to specifically cause cytotoxicity in cance...

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Detalhes bibliográficos
Main Authors: Clarke, John D., Hsu, Anna, Yu, Zhen, Dashwood, Roderick H., Ho, Emily
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129466/
https://ncbi.nlm.nih.gov/pubmed/21374800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201000547
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