Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3: MK2 MEDIATES LIPOPOLYSACCHARIDE-INDUCED SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION 3 (STAT3) ACTIVATION BY PREVENTING NEGATIVE REGULATORY EFFECTS OF MK3

In LPS-treated macrophages, activation of STAT3 is considered to be crucial for terminating the production of inflammatory cytokines. By analyzing the role of MAPK-activated protein kinase (MK) 2 and MK3 for LPS-induced STAT3 activation in macrophages, the present study provides evidence that MK2 is...

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Autors principals: Ehlting, Christian, Ronkina, Natalia, Böhmer, Oliver, Albrecht, Ute, Bode, Konrad A., Lang, Karl S., Kotlyarov, Alexey, Radzioch, Danuta, Gaestel, Matthias, Häussinger, Dieter, Bode, Johannes G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129192/
https://ncbi.nlm.nih.gov/pubmed/21586572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235275
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