IL-1β-induced and p38(MAPK)-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification

The IL-1β induced activation of the p38(MAPK)/MAPK-activated protein kinase 2 (MK2) pathway in hepatocytes is important for control of the acute phase response and regulation of liver regeneration. Many aspects of the regulatory relevance of this pathway have been investigated in immune cells in the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kulawik, Andreas, Engesser, Raphael, Ehlting, Christian, Raue, Andreas, Albrecht, Ute, Hahn, Bettina, Lehmann, Wolf-Dieter, Gaestel, Matthias, Klingmüller, Ursula, Häussinger, Dieter, Timmer, Jens, Bode, Johannes G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391758/
https://ncbi.nlm.nih.gov/pubmed/28223354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775023
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