IL-1β-induced and p38(MAPK)-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification

The IL-1β induced activation of the p38(MAPK)/MAPK-activated protein kinase 2 (MK2) pathway in hepatocytes is important for control of the acute phase response and regulation of liver regeneration. Many aspects of the regulatory relevance of this pathway have been investigated in immune cells in the...

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Vydáno v:J Biol Chem
Hlavní autoři: Kulawik, Andreas, Engesser, Raphael, Ehlting, Christian, Raue, Andreas, Albrecht, Ute, Hahn, Bettina, Lehmann, Wolf-Dieter, Gaestel, Matthias, Klingmüller, Ursula, Häussinger, Dieter, Timmer, Jens, Bode, Johannes G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391758/
https://ncbi.nlm.nih.gov/pubmed/28223354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775023
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