Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide

The p38(MAPK) downstream targets MAPKAP kinases (MK) 2 and 3 are critical for the regulation of the macrophage response to LPS. The extents to which these two kinases act cooperatively and distinctly in regulating LPS-induced inflammatory cytokine expression are still unclear. To address this uncert...

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Pubblicato in:Sci Rep
Autori principali: Ehlting, Christian, Rex, Julia, Albrecht, Ute, Deenen, René, Tiedje, Christopher, Köhrer, Karl, Sawodny, Oliver, Gaestel, Matthias, Häussinger, Dieter, Bode, Johannes Georg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6667695/
https://ncbi.nlm.nih.gov/pubmed/31363109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46791-8
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