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Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer

BACKGROUND: Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biological pathways of regulation. Most current approaches either depend on linear correlation or on nonparametric tests of asso...

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Autori principali: Solvang, Hiroko K, Lingjærde, Ole Christian, Frigessi, Arnoldo, Børresen-Dale, Anne-Lise, Kristensen, Vessela N
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128865/
https://ncbi.nlm.nih.gov/pubmed/21609452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-12-197
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