Anti-complement component C5 mAb synergizes with CTLA4Ig to inhibit alloreactive T cells and prolong cardiac allograft survival in mice

While activation of serum complement mediates antibody-initiated vascular allograft injury, increasing evidence indicates that complement also functions as a modulator of alloreactive T cells. We tested whether blockade of complement activation at the C5 convertase step affects T cell-mediated cardi...

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Main Authors: Raedler, H, Vieyra, M, Leisman, S, Lakhani, P, Kwan, W, Yang, M, Johnson, K, Faas, S.J., Tamburini, P, Heeger, PS.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128644/
https://ncbi.nlm.nih.gov/pubmed/21668627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2011.03561.x
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