Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver carcinoma and new therapies based on novel targets are needed. The tight junction protein claudin 1 (CLDN-1) is essential for HCV cell entry and spread, and anti-CLDN-1 rat and mouse mAbs are safe and effective in preventing and...

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Veröffentlicht in:J Gen Virol
Hauptverfasser: Paciello, Rolando, Urbanowicz, Richard A., Riccio, Gennaro, Sasso, Emanuele, McClure, C. Patrick, Zambrano, Nicola, Ball, Jonathan K., Cortese, Riccardo, Nicosia, Alfredo, De Lorenzo, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Microbiology Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478175/
https://ncbi.nlm.nih.gov/pubmed/26519290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000330
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