MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations result in the formation of chimeric MLL fusion proteins that act as potent drivers of acute leukemia. However, it remains unclear what portion...

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Detalhes bibliográficos
Main Authors: Wang, Qian-fei, Wu, George, Mi, Shuangli, He, Fuhong, Wu, Jun, Dong, Jingfang, Luo, Roger T., Mattison, Ryan, Kaberlein, Joseph J., Prabhakar, Shyam, Ji, Hongkai, Thirman, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128481/
https://ncbi.nlm.nih.gov/pubmed/21518926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324699
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