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MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome
MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations result in the formation of chimeric MLL fusion proteins that act as potent drivers of acute leukemia. However, it remains unclear what portion...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128481/ https://ncbi.nlm.nih.gov/pubmed/21518926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324699 |
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