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Molecular Dosimetry of N(2)-hydroxymethyl-dG DNA Adducts in Rats Exposed to Formaldehyde

In this study, both endogenous and exogenous N(2)-hydroxymethyl-dG adducts in nasal DNA of rats exposed to 0.7, 2, 5.8, 9.1 or 15.2 ppm [(13)CD(2)] formaldehyde for 6 h were quantified by a highly sensitive nano-UPLC-MS/MS method. Our data clearly demonstrated that exogenous formaldehyde DNA adducts...

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Hlavní autoři: Lu, Kun, Moeller, Benjamin, Doyle-Eisele, Melanie, McDonald, Jacob, Swenberg, James A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128468/
https://ncbi.nlm.nih.gov/pubmed/21155545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx1003886
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