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Use of LC-MS/MS and Stable Isotopes to Differentiate Hydroxymethyl and Methyl DNA Adducts from Formaldehyde and Nitrosodimethylamine

Formaldehyde is a known human and animal carcinogen that forms DNA adducts, and causes mutations. While there is widespread exposure to formaldehyde in the environment, formaldehyde is also an essential biochemical in all living cells. The presence of both endogenous and exogenous sources of formald...

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Hlavní autoři: Lu, Kun, Craft, Sessaly, Nakamura, Jun, Moeller, Benjamin C., Swenberg, James A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307879/
https://ncbi.nlm.nih.gov/pubmed/22148432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200426b
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