Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

Although MDM2 plays a major role in regulating the stability of the p53 tumor suppressor protein, other poorly understood MDM2-independent pathways also exist. Human adenoviruses have evolved strategies to regulate p53 function and stability to permit efficient viral replication. One mechanism invol...

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Detalhes bibliográficos
Main Authors: Querido, Emmanuelle, Blanchette, Paola, Yan, Qin, Kamura, Takumi, Morrison, Megan, Boivin, Dominique, Kaelin, William G., Conaway, Ronald C., Conaway, Joan Weliky, Branton, Philip E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2001
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC312842/
https://ncbi.nlm.nih.gov/pubmed/11731475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.926401
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