Identification of Three Functions of the Adenovirus E4orf6 Protein That Mediate p53 Degradation by the E4orf6-E1B55K Complex

Complexes containing adenovirus E4orf6 and E1B55K proteins play critical roles in productive infection. Both proteins interact directly with the cellular tumor suppressor p53, and in combination they promote its rapid degradation. To examine the mechanism of this process, degradation of exogenously...

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Detalhes bibliográficos
Main Authors: Querido, Emmanuelle, Morisson, Megan R., Chu-Pham-Dang, Huan, Thirlwell, Sarah W.-L., Boivin, Dominique, Branton, Philip E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC113966/
https://ncbi.nlm.nih.gov/pubmed/11134283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.2.699-709.2001
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