The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1

Mutations in HepA-related protein (HARP, or SMARCAL1) cause Schimke immunoosseous dysplasia (SIOD). HARP has ATP-dependent annealing helicase activity, which helps to stabilize stalled replication forks and facilitate DNA repair during replication. Here, we show that the conserved tandem HARP (2HP)...

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Autores principales: Ghosal, Gargi, Yuan, Jingsong, Chen, Junjie
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
Materias:
Scientific Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128281/
https://ncbi.nlm.nih.gov/pubmed/21525954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.74
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